Setting up RahiTuber under WINE on Linux - Thanks to @theflib for the tips!
RahiTuber works under WINE on Linux.
There is also a beta release built for linux ubuntu, but if that doesn't meet your needs, you can try this alternative setup.
Notes on Hotkeys (may be fixed now that I'm no longer using keyboard hooks to detect them):
The only problem is that hotkeys don't work while the window is out of focus, but this is due to a limitation in Wine.
In case any other Linux users come across this, It's possible to work around the problem by using a simplified version of the solution described here: https://www.howtogeek.com/125664/how-to-bind-global-hotkeys-to-a-wine-program-un...
Instead of creating separate script files, it works to just assign commands directly to the keyboard shortcuts in the Plasma system settings menu. Screenshot for reference: https://imgur.com/a/VJNefOO
Additional note for SAMMI users:
There was also the inverse issue of simulated button presses in SAMMI not being picked up. To work around that, put the xdotool command into a shell script and have SAMMI run that with a command: start /unix /bin/bash /home/foo/bar.sh