I do hope one day there's like "Pill swap" mode one day. What I mean is that each girl in their chapter has a base set of pills and this mode would allow you to swap the base sets (from there, who knows what happens), but for example, you can get Belle hooked on power pills, or you can use the cheese pill on like Celeste. If this happens (which is probably sadly unlikely), I wouldn't expect anything to be done with any duo chapters since yeah, that would be an insane amount of work.